THE DIRECT MEASUREMENT OF SERUM ZINC IN PREGNANT WOMEN AND ITS CORRELATION TO ALKALINE PHOSPHATASE.

Entela Treska, Kozeta Vaso, Shpresa Thomaj

Abstract


Zinc is recognized as essential for the activity of a wide range of enzymes. The first demonstration that zinc had a special biological function in relation to enzyme function,came with the discovery that carbonic Anhydrase contained significant amount of zinc which appeared to be required for normal activity. Alkaline phosphatase is a zinc-metalloenzyme that requires magnesium for activity and specific dietary deficiencies of either Zn or Mg, have been found to lower the alkaline phosphatase activity in serum. We took into consideration 100 cases of pregnant women, divided into groups according to fetus age, maternal age, zinc measurements, ALP activity etc. We measured serum zinc directly using by Atomic Absorption Spectrometry (VARIAN AAS-220) and at the same time alkaline phosphatase activity by a rapid method usin p-nitrophenyl phosphate. Data were analyzed to see if there was any positive correlation between serum zinc and alkaline phosphatase activity in all diseases: Preterm delivery, preeclampsia, anemia, cephalic, anomalies. As a conclusion, the statistical evaluation showed that there was a negative correlation between serum zinc and alkaline phosphatase activity in patients suffering from preeclampsia, whereas a positive correlation in diagnosis such as: preterm delivery, anemia, cephalic and anomalies.

Keywords: zinc in pregnancy, zinc and ALP, ALP and pregnancy, pregnancy complications.

 


References


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Prasad AS, Schulert AR, Sandstead HH et al. Zinc, iron and nitrogen content of sweat in normal and deficient subjects. Lab Clin Med 62: 84-89, 1963.


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ISSN : 2251-1563